The rising cost of the opioid antagonist and overdose reversal agent naloxone is an urgent public health problem. The recent and dramatic price increase of Evzio, a naloxone auto-injector produced by Kaléo, shows how pharmaceutical manufacturers entering the naloxone marketplace rely on market exclusivity guaranteed by the patent system to charge prices at what the market can bear, which can restrict access to life-saving medication. We argue that 28 U.S.C. § 1498, a section of the federal code that allows the (...) government to use patent-protected products for its own purposes in exchange for reasonable compensation, could be used to procure generic naloxone auto-injectors, or at least bring Kaléo to the negotiating table. Precedent exists for the use of § 1498 to procure pharmaceuticals, and it could give meaning to the federal government's recent declaration of a public health emergency around the opioid epidemic, discourage new market entrants from charging exorbitant prices, and yield important public health benefits. (shrink)

In recent years, a number of philosophers have conducted empirical studies that survey people's intuitions about various subject matters in philosophy. Some have found that intuitions vary accordingly to seemingly irrelevant facts: facts about who is considering the hypothetical case, the presence or absence of certain kinds of content, or the context in which the hypothetical case is being considered. Our research applies this experimental philosophical methodology to Judith Jarvis Thomson's famous Loop Case, which she used to call into question (...) the validity of the intuitively plausible Doctrine of Double Effect. We found that intuitions about the Loop Case vary according to the context in which the case is considered. We contend that this undermines the supposed evidential status of intuitions about the Loop Case. We conclude by considering the implications of our findings for philosophers who rely on the Loop Case to make philosophical arguments and for philosophers who use intuitions in general. (shrink)

Contingencies of the early nuclear arms race Content Type Journal Article Pages 1-23 DOI 10.1007/s11016-010-9495-z Authors S. S. Schweber, Department of the History of Science, Harvard University, Science Center 371, Cambridge, MA 02138, USA Alex Wellerstein, Department of the History of Science, Harvard University, Science Center 371, Cambridge, MA 02138, USA Ethan Pollock, Department of History, Box N, Brown University, Providence, RI 02912, USA Barton J. Bernstein, History Department, Building 200, Stanford University, Stanford, CA 94305-2024, USA Michael D. Gordin, (...) History Department, 305 Dickinson Hall, Princeton University, Princeton, NJ 08544, USA Journal Metascience Online ISSN 1467-9981 Print ISSN 0815-0796. (shrink)

The “fair benefits” approach to international research is designed to produce results that all can agree are fair without taking a stand on divisive questions of justice. But its appealing veneer of collaboration masks ambiguities at both a conceptual and an operational level. An attempt to put it into practice would look a lot like an auction, leaving little reason to think the outcomes will satisfy even minimal conditions of fairness.

Purpose There is a contradictive debate on factors influencing mobile phone usage awareness among scholars. This study aims to examine factors influencing mobile phone usage awareness for accessing agricultural marketing information. Design/methodology/approach A descriptive cross-sectional research design was used with 400 smallholder grape farmers. The use of structured questionnaires, focus group discussions and key informant interviews helped to collect primary data. Data analysis was subjected to descriptive, ordinal logistic regression and thematic approaches. Findings This study found that farmers were mostly (...) aware of voice calls helping to access buyers and price information. Education, age and sex were the critical factors influencing mobile phone usage awareness among grape smallholder farmers. Originality/value This study contributes to scientific knowledge by providing an understanding of the perceived factors on mobile phone usage awareness within the grape subsector to inform policymakers. (shrink)

This essay presents an integrated account of Michael Wyschogrod's Zionism as a function of his broader theological anthropology, eschatology, and carnal interpretation of Israel's election. Against Leora Batnitzky, I show that Wyschogrod's Zionism, while definitively messianic, is decidedly not fanatical or fundamentalist. Against Meir Soloveichik, I show that Wyschogrod has maintained this non-fanatical messianism consistently throughout his career, and so his pacific political prescriptions are organically at one with his vigorous calls for Jewish sovereignty over the land.

The Isis bibliography of the history of science has been published continuously since the first issue of the journal in 1913. This essay examines how information practices used to produce the bibliography have shaped, and were shaped by, the evolving discipline of the history of science. We first focus on the intellectual endeavors of George Sarton, who used the bibliography to help define and create a new academic field: the history of science. Next, we outline the administrative struggles of the (...) History of Science Society (HSS) as it tried to continue the project after Sarton’s retirement. Finally, we examine the technological aspects of producing a bibliography by focusing on the transition from analog to digital technologies over the last fifty years. In this overview, we show the central place the Isis bibliography played in the HSS community and argue that information practices surrounding the bibliography are an underutilized resource for studying the history of the discipline. (shrink)

This article proposes building on the success of publicly funded drug research and development and expanding the model to include the full cycle development, testing, manufacture and distribution of innovative and affordable new drugs.

The volume investigates the question of meaning of mystical phenomena and, conversely, queries the concept of "meaning" itself, via insights afforded by mystical experiences. The collection brings together researchers from such disparate fields as philosophy, psychology, history of religion, cognitive poetics, and semiotics, in an effort to ascertain the question of mysticism's meaning through pertinent, up-to-date multidisciplinarity. The discussion commences with Editor's Introduction that probes persistent questions of complexity as well as perplexity of mysticism and the reasons why problematizing mysticism (...) leads to even greater enigmas. One thread within the volume provides the contextual framework for continuing fascination of mysticism that includes a consideration of several historical traditions as well as personal accounts of mystical experiences: Two contributions showcase ancient Egyptian and ancient Israelite involvements with mystical alterations of consciousness and Christianity's origins being steeped in mystical praxis; and four essays highlight mysticism's formative presence in Chinese traditions and Tibetan Buddhism as well as medieval Judaism and Kabbalah mysticism. A second, more overarching strand within the volume is concerned with multidisciplinary investigations of the phenomenon of mysticism, including philosophical, psychological, cognitive, and semiotic analyses. To this effect, the volume explores the question of philosophy's relation to mysticism and vice versa, together with a Wittgensteinian nexus between mysticism, facticity, and truth; language mysticism and "supernormal meaning" engendered by certain mystical states; cognitive-poetic analysis of mystical poetry; and a semiotic scrutiny of some mystical experiences and their ineffability. Finally, the volume includes an assessment of the so-called New Age authors' contention of the convergence of scientific and mystical claims about reality. The above two tracks are appended with personal, contemporary accounts of mystical experiences, in the Prologue; and a futuristic envisioning, as a fictitious chronicle from the time-to-come, of life without things mystical, in the Postscript. The volume contains fourteen chapters; its international contributors are based in Canada, Israel, United Kingdom, and the United States. (shrink)

Bringing together original essays by French, British and American scholars, this collection explores the key role of gender and sexual politics in 20th-century French cinema.

We agree with Vaesen that there is evidence for cognitive differences between humans and other primates. However, it is too early to draw firm conclusions about the uniqueness of the cognitive mechanisms underlying human tool use. Tests of causal understanding are in their infancy, as is the study of animals more distantly related to humans.

Stephen Finlay’s book Confusion of Tongues is extraordinarily sophisticated, ambitious and thought-provoking. I highly commend it to those who haven’t read it yet. I will begin this commentary with a summary of which big-picture issues Finlay and I agree on and which we disagree on.

This paper explores relational syllogistic logics, a family of logical systems related to reasoning about relations in extensions of the classical syllogistic. These are all decidable logical systems. We prove completeness theorems and complexity results for a natural subfamily of relational syllogistic logics, parametrized by constructors for terms and for sentences.

Robotic warfare has now become a real prospect. One issue that has generated heated debate concerns the development of ‘Killer Robots’. These are weapons that, once programmed, are capable of finding and engaging a target without supervision by a human operator. From a conceptual perspective, the debate on Killer Robots has been rather confused, not least because it is unclear how central elements of these weapons can be defined. Offering a precise take on the relevant conceptual issues, the article contends (...) that Killer Robots are best seen as executors of targeting decisions made by their human programmers. However, from a normative perspective, the execution of targeting decisions by Killer Robots should worry us. The article argues that what is morally bad about Killer Robots is that they replace human agency in warfare with artificial agency, a development which should be resisted. Finally, the article contends that the issue of agency points to a wider problem in just war theory, namely the role of moral rights in our normative reasoning on armed conflict. (shrink)

This much-anticipated book is a detailed elaboration and defense of Levine’s influential claim that there is an “explanatory gap” between the mental and the physical.

I have not met a German yet who is well disposed toward Jews … The Jews, however, are beyond any doubt the strongest, toughest, and purest race now living in Europe.1Robert Holub’s Nietzsche’s Jewi...

This paper reconstructs Foucault's concept of illegalism and explores its significance for his genealogies of modern punishment and racial formation. The concept of illegalism, as distinct from illegality, plays a double role. It allows Foucault to describe a ruling class tactic for managing inequalities and also to characterize an important vein of resistant subjugated knowledges. The political project of the prison is linked to a new crime policy that does not so much aim to repress illegalisms as to manage them (...) differentially. This practice of differential management, which arises in the 18th century, produces a primary split along class lines between two types of illegalism—an insight that has a certain resonance with Edwin's Sutherland's concept of “white collar crime.” Foucault's investigation of a third category of “infralegal illegalism” sheds light not only on the genealogy of the category of delinquency but also on his genealogy of racial categorization. Finally, Foucault argues that a genuinely radical critique of modern society must address the “need” organized political power has for the illegalisms from which it purportedly seeks to protect society. Against this practice of differentially managing illegalisms, Foucault seeks to reactivate a subjugated problematic that might open up questions about the transformative possibilities of illegalism today. (shrink)

In his seminal paper ‘Truth’, M. Dummett considered negated conditional statements as one of the main motivations for introducing a three-valued logical framework. He left a sketch of an implication connective that, as we observe, shares some intuitions with Wansing-style account for connexivity. In this article, we discuss Dummett’s ‘unfinished’ implication and suggest two possible reconstructions of it. One of them collapses into implication from W. Cooper’s ‘Logic of Ordinary Discourse’ \(\textbf{OL}\) and J. Cantwell’s ‘Logic of Conditional Negation’ \(\textbf{CN}\), whereas (...) the other turns out to be previously unknown implication connective and can be used to obtain a novel logical system, entitled here as \(\textbf{cRM}_\textbf{3}\). As to the technical results, we introduce a sound and complete axiomatic proof-system for \(\textbf{cRM}_\textbf{3}\) and present a theorem for the semantic embedding of \(\textbf{CN}\) into \(\textbf{cRM}_\textbf{3}\). (shrink)

Saul Kripke’s much discussed Wittgenstein on Rules and Private Language has, I believe, been widely misinterpreted. The purpose of this note is to offer a correction. As it happens, on my reading of Kripke’s text Kripke’s Wittgenstein begins to look recognisably like Wittgenstein himself. But I shall not be concerned here with the question of whether Kripke’s Wittgenstein is Wittgenstein. My only aim is to correct the misinterpretation.

Foucault’s contribution to the critical theorization of race and racism has been much debated. Most commentators, however, have focused on his most direct remarks on the topic, which are found in the first volume of the History of Sexuality and in the lecture course “Society Must Be Defended.” This paper argues that those remarks should be reread in light of certain moves Foucault makes in earlier lecture courses, especially The Punitive Society and Psychiatric Power. Although the earlier courses do not (...) always explicitly address the theme of race, the concepts of the “accumulation of men” and the differential “management of illegalisms” developed in them immensely enrich Foucault’s outline of a genealogy of racism. They also permit a clarification of the problem to which the concept of “state racism” is an answer, and they provide the key for understanding the wider social conditions of state racism. The guiding thread linking these earlier courses to the later material is the problem of a genealogy of logics of enmity. At the same time, the earlier courses make explicit the link between these logics and the development of capitalist society. (shrink)

The idea that there is a fundamental difference in value between persons and things, and that respecting this difference is an important moral requirement, has strong intuitive appeal. Kantian ethics is unique in placing this requirement at the center of a moral system and in explicating the conditions for complying with it. Unlike challenges to Kantian ethics that focus on tragic cases that pit respect for one person against respect for another, this paper focuses on the question of how we (...) can respect the value distinction between persons and things under conditions of uncertainty. After exploring why decision making under uncertainty is a neglected topic among Kantians and demonstrating how uncertainty challenges our ability to comply with this norm, we propose a notion of morally insignificant risk within a framework that allows agents to navigate real-world decisions involving material benefit and some risk to dignity without violating the Kantian’s core commitments. We conclude by exploring some of the challenges facing this approach. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Keaton’s Yoke ALEX PRIOU Love, looking at me meltingly under dark-lidded eyes, by all manner of charms throws me into the limitless fishing-net of the Cupridian [Aphrodite]. And I tremble as he approaches, just as an aged, yoke-carrying horse that has carried off victory unwillingly walks into contest with swift chariots. (Ibycus, frag. 287)1 The resurgence of love in his old age prompts a fearful reflection in the (...) aged Ibycus. Love sets a trap he must escape, but cannot for all its infinitude, just as an athlete’s prior victories never sate his love of competition. Ibycus discovers the paradox of his situation, that the satisfaction sought is immeasurably greater than what a finite victory could ever provide. The competition of rival lovers for the beautiful beloved appears to Ibycus to be an immediate contrivance for an ineluctably distant object. Ibycus thus learns that love is human finitude’s attempt to answer the question that it itself raises. And yet, despite his fear, Ibycus’ reflection seems more comic than tragic, for his bestial image of love’s effects subverts all pretense to participation in the divinity of Aphrodite. The thought that the ultimate object of love’s longing is spurious may engender fear, but fear, in giving us an acute sense of our mortal limits, has the potential to take us outside ourselves and so prepare us for laughter. For reasons this tattered remnant of Ibycus’ poem doesn’t give us, the apparent tragedy of love—of the simultaneous necessity of pursuing the beloved and impossibility of complete satisfaction—appears resolved by our very awareness of it.2 Thankfully, Ibycus’ vision of love as both tragic and comic has a striking corollary in the films of Buster Keaton, who arion 26.3 winter 2019 mirrors the tension between yoked racehorse and reflective poet in the determined striving of his protagonists and the reflective depth of his directing. As both actor and director, Keaton is both striving body and disembodied thought, both trapped in finitude and reflecting thereupon. Ibycus and Keaton may bear love’s yoke, but they know the yoke’s on them. Keaton’s films thus promise some glimpse into the possibility of a comic redemption to the tragedy of lover and beloved, so much so that it seems one can connect these tatters of papyrus using celluloid film. Can the finite, particular beloved ever satisfy the lover, who strives to escape the limits of finitude? Or must we resign ourselves to our own transience? Keaton explores these questions by crafting comedies around characters who so strive. These characters—strikingly similar in their circumstances and ambitions, yet with slight but essential differences in disposition—offer Keaton a way to look for who bears easiest the weight of love’s yoke. I’ve chosen four films—Cops, College, The Playhouse, and The General—that, when ordered thus, bring us gradually from unavoidable tragedy to the unwitting self-redemption that comes when we laugh at ourselves. Discussing each in turn, I hope to offer some glimpse into what Ibycus may have had in mind when he playfully cast man’s most distinctive and serious striving as a yoked horse. CO P S (1922) the burden of love’s yoke is nowhere clearer in Keaton’s films than in Cops, as the film’s ominous epigraph warns: “Love laughs at locksmiths.” Keaton the director elegantly and humorously frames Keaton’s character as among love’s prisoners. The first shot features him behind bars, gripping them from within what appears to be a jail cell, as he and his love interest carry on a discussion with forlorn looks on their faces. Because the camera is on her side of the bars, we are invited to imagine ourselves free from Keaton’s predicament. She bids him farewell, and as she walks away Keaton the 116 keaton’s yoke director cuts to the other side of the bars and at a greater distance from the action. We discover that he isn’t in jail, but standing outside the gates to a great mansion. Keaton’s love interest turns around and speaks again, now stern rather than solemn. An intertitle finally... (shrink)

This article uses Foucault’s lecture courses to illuminate his reading of Marx’s Capital in Discipline and Punish. Foucault finds in Marx’s account of cooperation a precedent for his own approach to power. In turn, Foucault helps us rethink the concepts of productive force and labour power in Marx. Foucault is shown to be particularly interested in one of Marx’s major themes in Capital, parts III–IV: the subsumption of labour under capital. In Discipline and Punish and The Punitive Society, Foucault offers (...) a genealogy of the forms of labour power ( Arbeitskraft) and productive force ( Produktivkraft). One of his central problems is to understand how labour power is converted in productive force and how, prior to that, productive subjects who can properly bear and dispose of their labour power are formed. Foucault’s reading of Capital resonates with those currents of Marx interpretation today that seek to repoliticize the concept of productive force and to offer a materialist account of subject formation. (shrink)

The article considers what happened to the Buddhist concept of self-awareness ( svasaṃvedana ) when it was appropriated by Śaiva Siddhānta. The first section observes how it was turned against Buddhism by being used to attack the momentariness of consciousenss and to establish its permanence. The second section examines how self-awareness differs from I-cognition ( ahampratyaya ). The third section examines the difference between the kind of self-awareness elaborated by Rāmakaṇṭha (‘reflexive awareness’) and a kind elaborated by Dharmakīrti (‘intentional self-awareness’). (...) It is then pointed out that Dharmakīrti avails himself not only of intentional self-awareness but also of reflexive awareness. Some remarks on the relationship between these two strands of Dharmakīrtian Buddhism are offered. The conclusion points out that although self-awareness occurs in Buddhism as inextricably linked with anātmavāda , the doctrine of no-self, and sākāravāda , the view that the forms we perceive belong not to external objects but to consciousness, it is used by Rāmakaṇṭha to refute both of these views. An appendix addresses the problem of how precisely to interpret Dharmakīrti’s contention that conceptual cognition is non-conceptual in its reflexive awareness of itself. (shrink)

This paper expands the definition of gray-marketing to include some ethically problematic marketing activities and techniques used in personal selling in China. Based on this, a conceptual model of gray-marketing for a particular type of selling in which both the sellers and the buyers exhibit problematic ethics in an exchange and the associated hypotheses are developed and tested. The findings show that, first, the respondents have different ethical evaluations of different marketing practices used in personal selling such as giving and (...) accepting gifts, buying and accepting meals, and offering and accepting kickbacks. Some of these practices may not be considered unethical. Second, in terms of ethical assessment, gray-marketing practiced by buying agents is more unacceptable than when practiced by sales agents. Third, a person's ethical evaluation of gray-marketing behavior, empathy for gray-marketing, and belief that gray-marketing has serious consequences, significantly affects his inclination to use gray-marketing. This paper concludes with a discussion of some possible applications of our research findings. (shrink)

Interpreters of Plato’s Parmenides have long agreed that it is a canonical work in the history of ontology. In the first part, the aged Parmenides presents a devastating critique of Platonic ontology, followed in the second by what purports to be a response to that critique. But despite the scholarly agreement as to the general subject matter of the dialogue, what makes it one whole has nevertheless eluded its readers, so much so that some have even speculated it to be (...) a patchwork of two dimly related dialogues. -/- In Becoming Socrates, Alex Priou shows that the Parmenides’ unity remains elusive due to scholarly neglect of a particular passage in Parmenides’ critique—a passage Parmenides identifies as the hinge between the dialogue’s two parts and as the “greatest impasse” facing Platonic ontology. There Parmenides situates the concern with ontology or the question of being within the concern with political philosophy or the question of good rule. In this way, the Parmenides shows us how a youthful Socrates first learned of the centrality of political philosophy that would become the hallmark of his life—that it, and not ontology, is “first philosophy.”. (shrink)

IN BOTH THE EUDEMIAN ETHICS AND THE NICOMACHEAN ETHICS, Aristotle says that the aim of ethical inquiry is a practical one; we want to know what virtue is so that we may become good ourselves and thereby do well and be happy. By classifying ethical inquiry as a practical endeavor, Aristotle is rejecting a view that he attributes to Socrates according to which ethics is a kind of theoretical science. In theoretical sciences, such as geometry or astronomy, the knowledge of (...) a particular subject matter is sought as an end in itself, and the possession of such knowledge is sufficient to make one a geometer or an astronomer. In rejecting this model Aristotle argues that the knowledge of virtue is sought not solely for itself but in order to inform praxis and in order that we become virtuous and good, not by knowing what the virtues are but by cultivating them in practice. (shrink)

This paper examines the use of case studies in ethics education. While not dismissing their value for specific purposes, the paper shows the limits of their use. While agreeing that case studies are narratives, although rather thin stories, the paper argues that the claim that case studies could represent reality is difficult to sustain. Instead, the paper suggests a way of using stories in ethics teaching that could be more real for students, while also giving them a way of thinking (...) about their own professional practices. The paper shows how the method can be used to develop a more critical and reflective practice for students in the health care professions. Some immediate problems with the method are discussed. (shrink)

Objectives: The COVID-19 pandemic is having a major impact on the lives of everyone, but in particular on the health and well-being of older people. It has also disrupted the way that individuals access services and interact with one another, and physical distancing and “Stay at Home” orders have seen digital interaction become a necessity. While these restrictions have highlighted the importance of technology in everyday life, little is known about how older adults have responded to this change. Methods: Two (...) surveys, one in 2019 and another in 2020 collected data on a combined total of 1923 older adults aged 65 years and older in Canada. These looked at how older adults think about and use technology, with the 2020 survey additionally questioning how COVID-19 has impacted their use and attitudes towards technology. Results: While older adults feel more isolated in 2020, many feel positive about the benefits of technology and have increased technology use during the pandemic to support their health, wellness, and communication needs. Discussion: The results highlight the potential of technology for supporting older adults in various aspects of healthy aging. While these results point to the opportunities afforded by technology, challenges remain, such as how social and economic factors influence technology uptake. (shrink)

Martin Buber is considered one of the twentieth century’s greatest thinkers, contributing to the fields of philosophy, theology and education. After Buber’s death the appreciation of his considerable legacy became rather muted, but was never completely forgotten. Recently, interest in Buber’s thought has increased and a number of journal articles and books dealing with both general and specific aspects of his philosophy have appeared. However, the number of commentaries on the importance of his socio-political thought are still small in number, (...) and it is arguable that only Mendes-Flohr and Avnon have provided significant discussions on this aspect of Buber’s philosophy. This article adds to the debate in this area by referring to Buber’s concept of the ‘living-centre’, and assesses the Mendes-Florian and Avnonian [my terminology] interpretations of this fundamental idea so as to establish which provides a more sustainable reading of Buber’s ideas. (shrink)